MMJ Ingredient Prevents Brain Damage in Mice
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MMJ Ingredient Prevents Brain Damage in Mice
Posted by CN Staff on May 31, 2013 at 06:54:34 PT
By Geoffrey Mohan
Source: Los Angeles Times
Israel -- The words “marijuana” and “brain damage” usually go in that order in medical literature. An Israeli researchers has flipped them around, finding that THC, the active ingredient in marijuana, may arrest some forms of brain damage in mice. The loco weed already is favored by those who suffer from chronic diseases, not to mention fans of Cypress Hill, Bob Marley and the Grateful Dead.But pharmacologist Josef Sarne of Tel Aviv University found that a minuscule amount of tetrahydrocannabinol may protect the brain after injuries from seizures, toxic drug exposure or a lack of oxygen.
The amounts wouldn’t qualify as much more than a second-hand whiff of kine bud – the quantity of THC is an order of 1,000 to 10,000 lower than that in a whole spliff.The new dope on marijuana was published in Behavioural Brain Research and Experimental Brain Research, which are professional journals, not nicknames for HempCon or Burning Man.Other researchers didn’t tend to Bogart the joint as much. They suggested using high -- their word -- doses within about half an hour after such injury. Sarne would spread a smaller dose over as much as a week.The chemical is thought to jump-start biochemical processes that protect brain cells and preserve cognitive function.Researchers injected mice with a low dose of THC either before or after exposing them to brain trauma. Fellow rodents in a control group got their brains bonked without the dose.About a month or two later, the mice that got the THC treatment performed better in behavioral tests measuring learning and memory and showed they had greater amounts of neuroprotective chemicals than the control-group mice.Oddly, it may be brain damage on a small scale that causes the brain to shift into protective mode. Researchers theorize the THC causes minute damage to the brain that helps build resistance and triggers protective measures in the face of more severe injury.The low dose and long window for administering it would have obvious benefits after an injury, but it also could mean that THC can be given prior to a procedure that may carry risk of brain injury, including interruption of blood flow to the brain during surgery. Sarne believes it also could be safe for regular use among epileptics.Source: Los Angeles Times (CA)Author:  Geoffrey MohanPublished: May 31, 2013Copyright: 2013 Los Angeles TimesContact: letters latimes.comWebsite:  Medical Marijuana Archives 
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Comment #11 posted by The GCW on June 02, 2013 at 17:34:33 PT
Hemp foods have minuscule amounts of THC.
"a minuscule amount of tetrahydrocannabinol may protect the brain"I've been thinking about that for a few days now. Wonder if eating hemp seed oil, hemp seeds, hemp protein etc. with it's minuscule amount of THC is helpful? For people living in states where medical use of cannabis is still prohibited but have access to hemp products in health food stores.-For those citizens who would not do something illegal even if it prevented brain damage...
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Comment #10 posted by FoM on May 31, 2013 at 20:27:53 PT
I am sorry to read that happened to your horse. Loco Weed is really dangerous. 
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Comment #9 posted by keninsj on May 31, 2013 at 19:54:04 PT:
Loco Weed Causes severe problems in Horses
I had a mare that got in to loco weed, she was never the same again, she became permanently lethargic and lost all of her liveliness. It was very sad. I would never mention the two in the same sentence. 
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Comment #8 posted by observer on May 31, 2013 at 13:55:46 PT
Loco Weed: For The Government Tells Me So
But the US Government says that there marihuana is loco weed. Government says it; I Believe it; that settles it.
Marihuana is a most virile and powerful stimulant. The physiological effect of this drug produces a peculiar psychic exaltation and derangement of the central nervous system. [...] 
Prolonged use of marihuana frequently develops a delirious rage which sometimes leads to high crimes, such as assault and murder. Hence marihuana has been called the "killer drug." The habitual use of this narcotic poison always causes a very marked mental deterioration and sometimes produces insanity. Hence marihuana is frequently called "loco weed." (Loco is the Spanish word for crazy.)While the marihuana habit leads to physical wreckage and mental decay, its effects upon character and morality are even more devastating. The victim frequently undergoes such degeneracy that he will lie and steal without scruple; he becomes utterly untrustworthy and often drifts into the underworld where, with his degenerate companions, he commits high crimes and misdemeanors., it's all right there in the report on the LaGuardia Committee Report. Government (and I get a lump in my throat when I think of all the good things government does for the children) merely wants to do good and justice - in order to save the children! Sure, it always comes down to government putting a gun against your head to take stuff from you (money, property, rights, your life, etc) but they only have the best interests of children at heart! Don't you see? Is it not apparent? Do not we observe this on TV and in the papers? Government is Right! (Reich) Right? If government says cannabis is "loco weed" I better go along to get along. Thank you, O Government, for bringing light to me in my ignorance! To you we sing our high praises O Our Beloved Government - and especially those in government uniforms: Your Servants the police and military. When you say "loco weed" ours is not to question why, ours is to be obedient or be executed on the spot by your Government-sword-bearing servant - in the name of thee, O Government. If thou sayest "loco weed", then "loco weed" we shall treat it as, O Government whom we worship most obediently! Let us pray: Government is Great; Government is good: let us thank Government for our food. By Government's hand we all are fed: let us thank Governmental departments for our bread. Amen! I feel better now.
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Comment #7 posted by FoM on May 31, 2013 at 08:16:58 PT
I agree Loco Weed doesn't have THC.
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Comment #6 posted by FoM on May 31, 2013 at 08:16:09 PT
Related Article From The Times of India
Marijuana Can Help Prevent Brain DamageMay 31, 2013Tel Aviv University researchers have found that extremely low doses of THC — the psychoactive component of marijuana — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs. Brain damage can have consequences ranging from mild cognitive deficits to severe neurological damage. Previous studies focused on injecting high doses of THC within a very short time frame — approximately 30 minutes — before or after injury. The current research by Prof. Yosef Sarne of Tel Aviv University''s Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine demonstrates that even extremely low doses of THC — around 1,000 to 10,000 times less than that in a conventional marijuana cigarette — administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jumpstart biochemical processes which protect brain cells and preserve cognitive function over time. This treatment, especially in light of the long time frame for administration and the low dosage, could be applicable to many cases of brain injury and be safer over time, Prof. Sarne said. While performing experiments on the biology of cannabis, Prof. Sarne and his fellow researchers discovered that low doses of the drug had a big impact on cell signalling, preventing cell death and promoting growth factors. This finding led to a series of experiments designed to test the neuroprotective ability of THC in response to various brain injuries. In the lab, the researchers injected mice with a single low dose of THC either before or after exposing them to brain trauma. A control group of mice sustained brain injury but did not receive the THC treatment. When the mice were examined 3 to 7 weeks after initial injury, recipients of the THC treatment performed better in behavioral tests measuring learning and memory. Additionally, biochemical studies showed heightened amounts of neuroprotective chemicals in the treatment group compared to the control group. The use of THC can prevent long-term cognitive damage that results from brain injury, the researchers concluded. One explanation for this effect is pre- and post-conditioning, whereby the drug causes minute damage to the brain to build resistance and trigger protective measures in the face of much more severe injury, explained Prof. Sarne. The low dosage of THC is crucial to initiating this process without causing too much initial damage. According to Prof. Sarne, there are several practical benefits to this treatment plan. Due to the long therapeutic time window, this treatment can be used not only to treat injury after the fact, but also to prevent injury that might occur in the future. For example, cardiopulmonary heart-lung machines used in open heart surgery carry the risk of interrupting the blood supply to the brain, and the drug can be delivered beforehand as a preventive measure. In addition, the low dosage makes it safe for regular use in patients at constant risk of brain injury, such as epileptics or people at a high risk of heart attack. Prof. Sarne is now working in collaboration with Prof. Edith Hochhauser of the Rabin Medical Center to test the ability of low doses of THC to prevent damage to the heart. Preliminary results indicate that they will find the same protective phenomenon in relation to cardiac ischemia, in which the heart muscle receives insufficient blood flow. His research findings were published in the journals Behavioural Brain Research and Experimental Brain Research.
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Comment #5 posted by FoM on May 31, 2013 at 08:09:08 PT
Very true. I think that is why I see so many heavy drinkers in the RP. 
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Comment #4 posted by runruff on May 31, 2013 at 07:48:37 PT
Brain chemistry.
Alcohol and herione numb out the ,so called, spitual centers, in the brain. This is also the same section of the brain that deals in empathy. Empathy is what gives us our humanity. If you are void of empathy you are not an enlightened human being. They go togther.Why some relgions have named cannabis as their sacrament? cannabis stimulates and opens up the spiritual centers of our brains. 
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Comment #3 posted by HempWorld on May 31, 2013 at 07:47:02 PT
Loco weed does not produce THC!
Pot Garden
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Comment #2 posted by The GCW on May 31, 2013 at 07:14:10 PT
Amazing Grace
Cannabis is an amazing God-given plant. King of the plant kingdom. If there is a God in plant form, God is in cannabis.If the Christ Jesus can reach Us through plants (among other paths) or a plant, that plant is cannabis.Remember those cannabinoid receptor sites in the brain, which pretty much do nothing else but wait for THC to bind to them. Who put those there and why?With so much new medical related knowledge attributed to cannabis, becoming available so often, there is not much new knowledge of how cannabis helps spiritual realities, yet.Spiritual benefits of cannabis may be even greater and more important than medical use.
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Comment #1 posted by FoM on May 31, 2013 at 06:55:57 PT
Loco Weed?
This is Loco Weed not Cannabis.
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